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GEN
23 小时
Targeting “Proteolethargy” to Restore Protein Mobility May Represent Therapeutic ...
Researchers hope findings will lead to new class of drugs for many different diseases for which proteolethargy is a common ...
GEN
1 天
Rare Genetic Disorder Helps Explain Link Between Cancer Immunotherapy and Increased Infections
Studying patients with PD-1 or PD-L1 deficiency may help inform new approaches to fine-tuning immunotherapies to maximise ...
GEN
1 天
The Locus Coeruleus Acts as a Gatekeeper of Sleep Stages
The locus coeruleus was found to facilitate the transition between NREM and REM sleep states while maintaining an unconscious ...
GEN
1 天
Triggering Necroptosis in Tumor Cells Can Backfire in a Cloud of IL-1a
Cancer cell death via necroptosis can be accompanied by the release of IL-1a, which can restrict anticancer immunity and ...
GEN
1 天
Gene Signature for High-Risk Form of Acute Lymphoblastic Leukemia Identified by CHOP Scientists
ALL, certain drugs work for some patients who relapse, but these drugs are not effective for all patients who relapse.
GEN
2 天
Alzheimer’s Disease Neurodegeneration Held Back in Mice Treated Using Enzyme Inhibiting ...
In mice, inhibiting protein S-palmitoylation Counteracted accumulation of harmful proteins in neurons and delayed onset and progression of cognitive decline.
GEN
2 天
Novel Mechanism Unraveled in DNA Gyrase, Opening Pathways for Antibiotic Therapeutics
Using high-resolution cryo-electron microscopy researchers uncovered unprecedented detail of gyrase’s action on DNA.
GEN
2 天
Bitter Taste Receptor Engages Compounds Not Just Outside the Cell, but Inside
Bitter taste receptor has hidden intracellular pocket that enables activation via simultaneous extracellular/intracellular ...
GEN
3 天
Inceptor Binds Excess Insulin and Directs It Toward Degradation
Diabetes drug development gets an advance in study that shows Inceptor binds excess insulin within the beta cell and directs it towards degradation.
GEN
3 天
Bridgebio’s Attruby, to Treat Heart Condition ATTR-CM, Receives FDA Approval
Attruby (acoramidis), a near complete TTR stabilizer, has been approved by FDA to reduce cardiovascular death and ...
GEN
3 天
Xiaorong He on Boehringer Ingelheim’s Investments in AI, Broader Applications in Pharma
In this Q&A, He discussed Boehringer's investments in AI as well as areas where the technology could deliver greater value for pharma.
GEN
3 天
Trump to Nominate Makary for FDA Commissioner
Martin A. Makary, MD, of Johns Hopkins University, a critic of vaccination schedules and COVID-19 measures promulgated by ...
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