The blood-brain barrier border protects the brain by regulating the flow of molecules, peptides, and cells, but it also keeps ...

REAL AD hints that blood markers can spot subtle cognitive decline. People who fluff a digital cognitive test have more ...

In addition, Eisai must conduct a post-authorization safety study, including setting up a patient registry for the European Union. Now each European country must set its own rules for access and ...

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Scientists see several important uses for staging. For example, it can steer people more precisely to appropriate treatments.

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

The center collects, stores, and distributes pre- and postmortem tissues including brain, spinal cord, CSF, serum, blood cells, and urine. The center maintains inventories of its tissue and fluid ...