Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

Objective To fulfil an unmet therapeutic need for treating type 2 diabetes by developing an innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide-1 (GLP-1) and ...

Inflammatory bowel disease and Parkinson’s disease are chronic progressive disorders that mainly affect different organs: the gut and brain, respectively. Accumulating evidence has suggested a ...

Objective We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the ...

Correspondence to: K R Palmer, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK; kpalmer{at}golf5063.freeserve.co.uk “Medline” and “EMBASE” were searched to identify the evidence used in ...

Objective The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional ...

1 Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark 2 Center for Sensory-Motor Interactions, Department of Health Science and Technology, Aalborg University, ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

Objective Developing a small animal model that accurately delineates the natural history of hepatitis B virus (HBV) infection and immunopathophysiology is necessary to clarify the mechanisms of ...

Mounting evidence underscores the pivotal role of the intestinal barrier and its convoluted network with diet and intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and ...

1 Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA 2 Department of Medicine, Columbia University, New York, NY, USA 3 Institute of Human Nutrition, ...