Clinical data from the OT‑101 P001 PDAC study suggest that targeting TGFB2 merits additional evaluation in younger patients; ...

Phio Pharmaceuticals has been granted a patent for RNAi constructs used in gene silencing. The constructs consist of a double stranded region connected to a single stranded region containing ...

The Weihong Tan and Xue-Qiang Wang groups at Hangzhou Institute of Medicine (HIM, Chinese Academy of Sciences) have demonstrated the effectiveness of phosphorothioate backbone modification in ...

Achieve narrow peaks and high sensitivity by optimizing the separation of phosphorothioate oligonucleotides in 5 steps using the strong anion exchanger BioPro IEX QF.

Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro ...

This application note shows how to achieve narrow peaks and high sensitivity by optimising the AEX separation of phosphorothioate oligonucleotides (PS) in only 5 steps.

However, we lack quantitative understanding of the phosphorothioate DNA (PT-DNA) cleavage efficiency and the chemoselectivity of this method for determination of phosphorothioate vs. phosphate.

DNA phosphorothioate modification, in which a non-bridging oxygen in DNA phosphate backbone is replaced by sulfur, exists widely in bacteria. Originally, the modification was found in the ...