The authors also suggested that the combination of IHC with FISH or Q-RT-PCR in IHC equivocal cases or even in all tumors may be a reliable and moderate-cost strategy for HER2 status assessment.

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Future Oncol. 2015;11(7):1023-1026. Tumor-negative breast cancers misclassified as HER2 negative by IHC (0 or 1+) could therefore be reclassified by FISH, with a remarkable impact on medical ...

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