当前研究揭示了axSpA发病的双重机制：HLA-B27通过分子模拟和异常折叠触发CD8 + T细胞应答；中性粒细胞则通过分泌炎性介质和形成NETs参与HLA-B27非依赖途径。 针对TCR基序的单抗治疗和中性粒细胞相关靶点（如MIF、NETs）的干预策略，为开发精准治疗方案提供了新思路。

The legal arm of the National Rifle Association asked the Supreme Court on Friday to take up a new case that could expand gun rights for owners of AR-style rifles, challenging federal restrictions ...

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The NRA said Vullo pressured banks and insurance companies to blacklist it after the school shooting in Parkland, Florida, that left 17 people dead in 2018.

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For free speech advocates, the application of the NRA decision in cases pushing back against Trump’s retribution campaign is a welcome sign that lower courts are applying key First Amendment ...

本研究通过大规模质谱分析，揭示了强直性脊柱炎 (AS)相关HLA-B14:03和HLA-B27:05等位基因共享1011种特异性肽段，而与非AS相关HLA-B*14:02存在显著差异。研究人员发现单氨基酸差异 (L156R)通过远程作用影响肽段结合特性，为AS发病的'关节炎肽假说'提供了直接证据，对理解HLA-I分子在自身免疫疾病中的作用 ...

Background: A 36-year-old male presented with bilateral, anterior, chronic uveitis, with cystoid macular edema. Decimal visual acuity was 0.25 in the right eye and 0.20 in the left eye. Ankylosing ...

洪铁艳强调，强直性脊柱炎的诊断并不困难，在三甲医院通过B27检测和骶髂关节CT等检查即可确诊，“难的是很多人不知道自己患的是这个病，常去 ...