Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five ...

The Buffalo Bills are set to host another dangerous winter storm this Sunday with 2 to 3 feet of snow forecast ahead of ...

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.