The All-Pro went down almost immediately for a 5-yard loss. He went to the sideline and was examined in the medical tent.

San Francisco 49ers running back Christian McCaffrey bulldozes a Buffalo Bills defender into to the snowy gridiron during a 20-yard run.

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

San Francisco 49ers running back Christian McCaffrey is questionable to return to Sunday night's game against the Buffalo Bills with a knee injury.

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.

McCaffrey slid down untouched in the backfield after taking a toss, then immediately went to the 49ers’ medical tent and ...

San Francisco 49ers fans held their collective breath Sunday when Christian McCaffrey went down with a non-contact injury in ...

San Francisco star running back Christian McCaffrey exited the 49ers Sunday Night Football game against the Bills with a knee ...

Christian McCaffrey was off to a great start in Sunday night’s matchup with the Bills but had to exit the contest early in the second quarter.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The San Francisco 49ers might be without their Steph Curry for the rest of tonight's game against the Buffalo Bills. Head ...