Contributed by J. Wade Harper; received September 23, 2024; accepted October 30, 2024; reviewed by Pietro V. De Camilli and Michael Lazarou This contribution is part of the special series of Inaugural ...

Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. Traditionally, phase separation directly regulates cell functions by driving RNA, ...

This work was supported by the National Key R&D Program of China (No. 2023YFD1400800) and the Zhejiang Key Research and Development Program of China (Nos. 2020C02001 ...

All STEM fields are not the same. Gender stereotypes about computer science and engineering strongly diverge from those about math and science, and this holds across racially and socioeconomically ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2017. Contributed by Sang Yup Lee, August 17, 2018 (sent for review May ...

Contributed by Zhu Chen, October 17, 2018 (sent for review August 29, 2018; reviewed by Christine J. Harrison and Patrick Tan) ...

Amino acids (AAs) constitute a major component in intracellular biomolecules. More than 25% of the total volume of a mammalian cell was reported to be made of AAs. Here, we study how AAs affect the ...

S-palmitoylation is a lipid posttranslational modification process involved in diverse cellular events in a wide range of biological systems. It has remained unclear whether S-palmitoylation has a ...

Calcium enters mitochondria via the calcium uniporter to regulate energy production and survival. The uniporter activity is controlled by calcium via binding the EF-hands of the regulatory MICU ...

Information in biological entities is conveyed by solvated ion carriers in water environments, allowing integration, parallelism, and optimal power consumption to control motion, but it poses an ...

Research Reports describe the results of original research of exceptional importance. The preferred length of these articles is 6 pages, but PNAS allows articles up to a maximum of 12 pages. A ...

Healthy brain function requires a delicate balance of neural excitation (E) and inhibition (I). In animals, this balance—the E/I ratio—is known to decrease with the maturation of inhibitory circuitry ...