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GEN
23 小时
Targeting “Proteolethargy” to Restore Protein Mobility May Represent Therapeutic ...
Researchers hope findings will lead to new class of drugs for many different diseases for which proteolethargy is a common ...
GEN
1 天
Rare Genetic Disorder Helps Explain Link Between Cancer Immunotherapy and Increased Infections
Studying patients with PD-1 or PD-L1 deficiency may help inform new approaches to fine-tuning immunotherapies to maximise ...
GEN
1 天
Triggering Necroptosis in Tumor Cells Can Backfire in a Cloud of IL-1a
Cancer cell death via necroptosis can be accompanied by the release of IL-1a, which can restrict anticancer immunity and ...
GEN
1 天
The Locus Coeruleus Acts as a Gatekeeper of Sleep Stages
The locus coeruleus was found to facilitate the transition between NREM and REM sleep states while maintaining an unconscious ...
GEN
2 天
Novel Mechanism Unraveled in DNA Gyrase, Opening Pathways for Antibiotic Therapeutics
Using high-resolution cryo-electron microscopy researchers uncovered unprecedented detail of gyrase’s action on DNA.
GEN
2 天
Bitter Taste Receptor Engages Compounds Not Just Outside the Cell, but Inside
Bitter taste receptor has hidden intracellular pocket that enables activation via simultaneous extracellular/intracellular ...
GEN
3 天
Bridgebio’s Attruby, to Treat Heart Condition ATTR-CM, Receives FDA Approval
Attruby (acoramidis), a near complete TTR stabilizer, has been approved by FDA to reduce cardiovascular death and ...
GEN
3 天
Trump to Nominate Makary for FDA Commissioner
Martin A. Makary, MD, of Johns Hopkins University, a critic of vaccination schedules and COVID-19 measures promulgated by ...
GEN
4 天
StockWatch: Moderna Seeks to Reassure Investors on RFK Jr.
Moderna’s top executives have sought to reassure investors they will be able to carry out the comeback plans announced in ...
GEN
6 天
Repair Proteins Collaborate in “Hubs” to Repair DNA Damage
Researchers have mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...
GEN
1 天
Gene Signature for High-Risk Form of Acute Lymphoblastic Leukemia Identified by CHOP Scientists
ALL, certain drugs work for some patients who relapse, but these drugs are not effective for all patients who relapse.
GEN
6 天
snoRNA Target Discoveries Could Lead to Potential Therapeutic Strategies
A new approach for identifying new cellular RNA targets of snoRNAs uncovered thousands of previously unknown targets ...
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