Methods: This is a multicenter, randomized, double-blind, active-controlled, parallel-group, Phase 3 study (NCT05007392). Gout subjects with serum uric acid (SUA) level >7.0 mg/dL were randomized into ...

Objectives To evaluate the efficacy and safety of ianalumab (VAY736), a B cell-depleting, B cell activating factor receptor-blocking, monoclonal antibody, in patients with active primary Sjögren’s ...

Raynaud’s phenomenon (RP) with or without digital ulcer formation is a significant cause of morbidity for patients with systemic sclerosis (SSc, scleroderma). Lichtenstein reported oral sildenafil as ...

Objective To compare the relative bioavailability, safety and tolerability of oral methotrexate (MTX) and subcutaneous (SC) MTX administered via an auto-injector (MTXAI) in patients with rheumatoid ...

A century ago syphilis was regarded as the great masquerader. Its modern equivalent is lupus. It may present to a wide range of specialists and its outcome, while much improved, remains uncertain in a ...

Background: Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant imaging modality for diagnosis and classification of early axial spondyloarthritis (SpA) including ...

Objective: To compare the efficacy of aerobic walking and home based quadriceps strengthening exercises in patients with knee osteoarthritis. Methods: The Medline, Pubmed, EMBASE, CINAHL, and PEDro ...

Chimeric antigen receptors (CARs) are synthetic proteins designed to direct an immune response toward a specific target and have been used in immunotherapeutic applications through the adoptive ...

The burden of gout increased globally across the 20th and 21st centuries.1 However, a study using cross-sectional datasets demonstrated stable prevalence of hyperuricaemia and gout in the USA between ...

Gout is the most common inflammatory arthritis and one in which pathogenesis and risk factors are best understood. One of the treatment objectives in current guidelines is ‘cure’. However, audits show ...

Background Systemic lupus erythematosus (SLE) is becoming a public health concern because of increasing disease and economic burdens. However, epidemiological data on SLE, especially its incidence ...

Background Rheumatoid arthritis (RA) is highly heterogenous with distinct cellular and molecular tissue pathotypes that associate with disease outcome[1]. The synovial membrane is the primary target ...