AbstractBackground:. The five-year survival rate for colorectal cancer (CRC) remains at 14% despite improvements in early detection and the development of novel treatments, underscoring the need for ...

Multiple lines of correlative evidence support a role for angel homolog 2 (ANGEL2), a novel cancer-relevant RNA-binding protein, in the modulation of chemoresistance and survival of patients with ...

Abstract. Many cancers are curable if treated in time. This is the keynote of the educational campaign for the control of cancer. To reduce the delay in treatment is the first step in lessening the ...

The Cancer and Leukemia Group B (CALGB) began to take shape in 1953 when James F. Holland arrived at the National Cancer Institute (NCI) upon the opening of the Clinical Center and initiated a ...

1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 ...

AbstractPurpose:. Antibody–drug conjugates (ADC) are a promising approach for the management of patients with non–small cell lung cancer (NSCLC). However, only a small subset of patients derive ...

INK4–CDK6 complex promotes resistance to CDK4/6i in cells. A, Schematic for analysis of CDK4 and CDK6 interactions and activity via coimmunoprecipitation (co-IP) followed by ADP-Glo kinase assays and ...

It is well known that the majority of genetic variants or single nucleotide polymorphisms in the human genome are of low penetrance, including genes implicated in metabolism of environmental chemicals ...

In addition to exerting these diverse physiologic roles, TAp63 and ∆Np63 have opposite activities in tumor formation. TAp63 is a potent tumor and metastasis suppressor (13) and can regulate the ...

This work demonstrates that METTL3 inhibition stimulates a cell-intrinsic interferon response through dsRNA formation. This immunomodulatory mechanism is distinct from current immunotherapeutic agents ...

Abstract. The cancer early-detection biomarker field was, compared with the therapeutic arena, in its infancy when the Early Detection Research Network (EDRN) was initiated in 2000. The EDRN has ...

Cervical cancer is a relatively rare disease in countries that have instituted and maintained national screening programs, with call and recall of women at various intervals and built-in quality ...