Pediatric Research - B-cell hyperfunction in children with immune thrombocytopenic purpura persists after splenectomy Skip to main content Thank you for visiting nature.com.

The hyperfunction theory, an alternative idea that has emerged in biogerontology in recent years, allows that molecular damage does occur. The theory, however, also holds that such damage probably ...

Even in this heyday of probing research, many medical discoveries stem from chance observation. An example is the discovery of the adrenal inhibitor o,p′DDD. Toxicity studies on the insecticide ...

This finding was of particular significance in that only 1 patient, a woman with active acromegaly, had a basal urinary 17-ketosteroid level sufficiently above the normal range to alert the ...

A new research perspective was published in Aging (Aging-US) Volume 14, Issue 20, entitled, “Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice.” ...

Moreover, hyperfunction induces the hyperactivation of the DDR signaling pathways, although it is not a consequence of the accumulation of DNA damage itself. 75 Inhibiting or reducing this overload is ...