Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five ...

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

Buffalo Bills quarterback Josh Allen could become his team's sole all-time leading touchdown scorer in Week 13.

The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 ...

Yet on Sunday night in frigid Orchard Park, the 49ers, mired at 5-6 and a game out of first place in the NFC West, find their ...

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...

The Bills are activating Matt Milano (biceps) off injured reserve and the linebacker will make his long-awaited return on ...