图 1 a) FOS 和 BIOS 研究 策略； b) 所 提出的 POSS 策略并应用于 oridonin 与 maoelac t one A 中国科学院昆明植物研究所等提出了挖掘新颖 天然骨架潜在应用价值的 “Pharmacophore-Oriented Semisynthesis （ POSS ） ” 策略（图 1b ）。 该策略的研究思路在于将天然骨架 A 的药效团与新颖骨架 B 相结合， ...

The semisynthesis of nucleolar human selenoprotein H. Journal: Chemical Science Published: 2023-11-15 DOI: 10.1039/d3sc03059h Affiliations: 3 Authors: 4. Go to article. Institutions ...

Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A–C. Journal: Organic Letters Published: 2024-09-27 DOI: ...

Semisynthesis of Homogeneous Glycoproteins (IMAGE) Wiley. Caption. The efficient formation of mixed disulfides on the thiol-rich fusion protein A followed by subsequent intein cleavage gave ...

RESEARCH - Henning Mootz Protein chemistry / biotechnology Technology development for protein semisynthesis and protein functional control. The ability to site-selectively incorporate a synthetic ...

I will discuss our protein semisynthesis strategies to access “designer p53” and a viral anticancer protein bearing defined PTMs, and how we are deploying these proteins in functional assays in vitro ...

Because no practical synthetic route to this complex antibiotic is available, the quest for better performing analogs has been restricted to semisynthesis, whereby the natural product is isolated ...

Researchers have created a modified form of the approved antibacterial drug vancomycin (Vancocin) that has three independent mechanisms of action, boosting its potency and minimizing the potential ...