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化疗耐药不再无解?复旦大学提出胰腺癌治疗有效、协同新策略
临床上,超过 90% 的胰腺导管腺癌(PDAC)病例携带 KRAS 基因突变,具有高度侵袭性和恶性增殖的特点。KRAS 突变改变了 PDAC 的物质运输和代谢模式,导致其对化疗和免疫治疗产生内在耐药性。尽管一线临床治疗方案是化疗(吉西他滨 + ...
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