One of these No. 1 seeds is not like the other. Sports betting books list Duke as a clear favorite in the men's Final Four, but hang on just a second.

No. 1 seed Duke vs. No. 1 seed Houston has the makings of a March Madness classic (in April) at the Alamodome in San Antonio, Texas.

Take a look at the site's Final Four picks for the NCAA Tournament semifinal matchups, which start with the Florida Gators vs Auburn Tigers and conclude with the Duke Blue Devils vs Houston ...

Final Four picks, predictions, odds explain why Duke Blue Devils will beat Houston Cougars in NCAA Tournament March Madness game Saturday, April 5.

Final Four picks, predictions, odds for Duke Blue Devils vs Houston Cougars NCAA Tournament March Madness game Saturday, ...

Madness is almost over, but three big games remain. Here are our Duke vs. Houston predictions, picks and best bets for the ...

Final Four has finally arrived, and after an NCAA Tournament that started trending towards chalk from the earliest rounds, ...

The SportsLine Projection Model has revealed its picks for Cooper Flagg and the Duke Blue Devils vs. the Houston Cougars in ...

Houston's experience plus Kelvin Sampson's coaching prowess makes Cougars a tough Final Four opponent for Duke. Florida's Walter Clayton Jr., Auburn's Johni Broome accustomed to going toe to toe ...

Final Four picks, predictions, odds explain why Houston Cougars will beat Duke Blue Devils in NCAA Tournament March Madness game Saturday, April 5.

Check out these March Madness Final Four picks and predictions for the men's college basketball national semifinal matchup. Duke is a 4.5-point favorite over Houston in the game in March Madness ...