Polybasic cleavage site in SARS-CoV-2. The pathogenicity and interspecies transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ...

Made up of amino acids, SARS-CoV-2's polybasic cleavage sites have remained elusive since the COVID-19 outbreak began. But previous research indicates that these mysterious sites are essential for ...

A computer model showing the polybasic cleavage sites, located on the novel coronavirus' protein spike. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...

Furthermore, upon comparing sequences of the S1/S2 genomic region, remains of a polybasic FCS motif at the S1/S2 boundary in 12 of the 17 CoVs from Europe, Asia, and Africa were seen.

The team saw signs of natural selection acting on key coronavirus genome features such as the receptor-binding domain (RBD) sequences and sequences spanning so-called "polybasic cleavage sites ...