Nature Cell Biology - Phospholipase Cγ1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B Skip to main content Thank you ...

Among over 100 members of the PTP family, protein-tyrosine phosphatase 1B (PTP-1B) and T-cell protein-tyrosine phosphatase (PTPN2, TCPTP) have the most closely related homology (72%), sharing ...

PTP-1B phosphatase is implicated in insulin/leptin receptor activity and in cancer cells migration and invasion. PTP-1B could be a predictor marker of APF in PC. The aim was to compare the expression ...

Co announces new data from preclinical studies of trodusquemine (MSI-1436) for the treatment of obesity. The presentation summarized results from preclinical studies demonstrating that MSI-1436 is ...

CARLSBAD, Calif., Feb. 3, 2015 -- Isis Pharmaceuticals, Inc.(NASDAQ: ISIS) announced today top-line results from a Phase 2 study of ISIS-PTP1BRx in patients with type 2 diabetes. In the Phase 2 ...