The keratoderma-like phenotype we observe is associated with reduced expression of differentiation-associated cutaneous keratins, and increased expression of hyperproliferation-associated ...

TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel that functions as a regulator of skin homeostasis. The epidermal overexpression of TRPV3 is linked to dermatological ...

Figure 1 shows the psoriasiform, hyperkeratotic plaques typical of keratoderma blennorrhagicum (i.e., the acral pustular and hyperkeratotic lesions seen in Reiter's syndrome and pustular psoriasis 1).

Hereditary palmoplantar keratoderma, a well-known clinical entity, is illustrated through a familial report of an unmarried young man who is the product of a consanguineous marriage (paternal and ...

Palmoplantar keratodermas (PPKs) are divided into three types. Type I (the form most likely to be affecting our patient) is punctate keratoderma, which manifests with numerous hard wartlike dells ...

Researchers found genetic differences in hereditary palmoplantar keratoderma subtypes, indicating that genetic testing may be a valuable tool in accurately diagnosing the disease, according to a ...

Introduction. Pachyonychia congenita (PC) is a rare form of hereditary palmoplantar keratoderma (PPK) (Smith et al., 2001) and is a genetic disorder of keratinization that affects the nails, skin ...

--Sol-Gel Technologies, Ltd. today announced the initiation of a Phase 1 proof of concept clinical study of SGT-210, its novel, topical, epidermal growth factor receptor inhibitor in patients with ...

Both viral warts and keratoderma are benign but can cause problems on the hands. Failing to differentiate them can lead to inappropriate treatment - as occurred with the patient pictured here with ...

Did you know that certain medications can cause symptom of 'Acquired keratoderma'. Find these drugs listed on the page and be warned of similar symptoms as possible side-effects.