新预测的蛋白isoforms构成了数据库的重要部分。 其中75%基因至少有一个pNIC或pNNC；三分之一的基因对应的丰度最高的蛋白isoform与GENECODE 中的参考isoform不对应；且42.5% (1215)的蛋白isoforms是之前未发现过的，这进一步说明了构建样品特异性的蛋白数据库的重要性。

Isoforms can be produced through normal cellular processes and regulation, whereas variants often represent genetic changes or mutations that can be associated with diseases or genetic diversity ...

Increased demands for pDNA for emerging nucleic acid-based vaccines and therapies exacerbate the need to remove bottlenecks from production.

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other.

While all six isoforms are found in the adult human brain, adult mice normally express only 4R isoforms. Like humans, adult MAPT knock-in mice express all six tau isoforms, with the level of 4R mRNA ...

Inhibiting a protein isoform in the spinal cord alongside morphine improves the opioid’s pain-relieving properties without increasing unwanted side effects.

These were unable to distinguish the two natural 54- and 24-kilodalton isoforms, which arise through alternative splicing. In the July 14 Annals of Neurology online, scientists report two new C9ORF72 ...

Our study identifies thousands of novel brain expressed isoforms, and confirm the importance of alternative splicing in the cortex, dramatically increasing transcriptional diversity and ...

In addition, the study explored the role of the two isoforms in embryonic development. One of them, KRAS4B, "is key after birth, since in the absence of this variant, mice cannot grow as a result of ...

On April 24, 2023, a new research paper was published in Oncotarget, entitled, “Differential silencing of STAT3 isoforms leads to changes in STAT3 activation.” ...