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生物通
3月
SWI/SNF PBAF 复合物:解锁染色质抑制区域的关键 “钥匙 ...
为剖析 SWI/SNF(switch/sucrose non-fermentable)染色质重塑因子的独特功能,研究人员对黑色素细胞和黑色素瘤中的相关复合物及染色质状态进行表观基因组分析。结果发现 PBAF 区域对 ATP 酶抑制更不敏感,且 PBAF 影响 REST 结合染色质。这为疾病研究提供了新方向。
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