Skeletal radiological survey revealed no mandibular or clavicular hypoplasia, diffuse osteopenia and resorption of the distal phalanges predominantly involving the hands, and to a lesser extent ...

Radiographs of the left forearm showed diffuse osteopenia and degenerative changes of the wrist joint, without fractures or bone lesions.

Conclusions: Osteopenia was present in approximately 50% of patients with untreated FD. Whether BMD and bone metabolism will improve after enzyme replacement therapy remains to be established.