CD2AP与阿尔茨海默病：神经退行性疾病的关键调节因子及潜在治疗靶点 最新研究综述揭示CD2AP在淀粉样蛋白代谢、tau病理、突触功能和神经炎症中的 ...

脑内皮 CD2AP 减少的动物在静息和神经血管耦合时血流调节改变，壁细胞活动存在缺陷，对 Aβ 的血管反应存在性别差异。阻断内皮素 - 1 受体 A 信号可部分挽救血管损伤，但仅在雄性小鼠中有效。用 reelin 糖蛋白治疗 CD2AP 突变小鼠，通过 ApoER 2 减轻 CD2AP ...

Background: CD2AP is a multifunctional adaptor molecule, binding other key podocyte proteins within the slit-diaphragm complex. Methods: The cellular phenotype of conditionally immortalized wild ...

"CD2AP may play a dual role in amyloid regulation," explained Professor Zhang. "On one hand, it limits excessive Aβ production, and on the other, it helps remove toxic amyloid aggregates.

Impact of CD2AP deficiency in microglia in Alzheimer’s disease (AD). Microglial CD2AP levels are increased in AD, leading to elevated CSF1R signaling and C1q expression and cytoskeleton ...

“The Alzheimer’s disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin-binding adaptor protein, but its function in the nervous system is largely unknown.

"CD2AP brings in all the correct players, forms a multi-protein complex and coordinates that multi-protein complex to achieve growth of the neurons," Harrison said.

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. The Journal of Neuroscience , April 2016 DOI: 10.1523/JNEUROSCI.2423-15.2016 Cite This Page : ...

Mice lacking only one copy of the gene for CD2-associated protein (CD2AP) appear to be significantly more susceptible to kidney disease and failure than normal mice. Moreover, the mutation appears ...

Role of adaptor protein CD2AP in neuron sprouting discovered. GEN – Genetic Engineering and Biotechnology News ...