2025年5月21日南京医科大学鲁明教授团队在Science Advances杂志上发表文章揭示了慢性应激下星形胶质细胞来源的CCL5通过其受体CCR5驱动中性粒细胞浸润 ...

Furthermore, chemokines did not influence the proliferation of CXCR4 + or CCR5 + cell lines, even when the corresponding receptors were found to be functional by calcium flux or chemotaxis assay.

星形胶质细胞 CCL5 - 中性粒细胞 CCR5 趋化信号在抑郁模型中上调 对中性粒细胞的二次聚类分析显示，抑郁症患者和小鼠中 CCR5 + 中性粒细胞亚群显著增加。 同时，星形胶质细胞来源的 CCR5 配体 CCL5 在海马区表达上调，免疫共染色证实 CCL5 主要由星形胶质细胞产生。

CXCR4在肿瘤的生长、侵袭、血管生成和转移等发挥重要作用，而全球仅有两款药物获批上市的现状下，相信未来会有越来越多的新药成果涌现。

Here we show that in human lymphoid tissue ex vivo13,14,15, HHV-6 affects HIV-1 infection in a coreceptor-dependent manner, suppressing CCR5-tropic but not CXCR4-tropic HIV-1 replication, as shown ...

The CXCR4 and CCR5 receptors have been emerging as potentially effective therapeutic targets for Cancer and HIV therapy. This article discusses their potential efficacy.

通过比较CCR5分别与两种不同趋化因子结合的复合物结构，研究人员发现，与结合MIP-1α的受体相比，CCR5与RANTES结合后其第一和第二个跨膜螺旋向外 ...

Coreceptor-targeted Anti-HIV Therapy Along with CCR5, CXCR4 is a major coreceptor in HIV infection. R5 HIV-1 is isolated predominantly during the acute and asymptomatic stages, [38] whereas X4 HIV ...

Impact of Nonfunctional Chemokine Receptor Alleles on HIV Resistance & Disease Progression CCR5 δ32 is a mutant allele of CCR5 that is prevalent in European populations. [33] The gene product is ...

This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge ...

Comparison of the CCR5 structure with the previously determined CXCR4 structure also provided hints about an important aspect of HIV evolution during infections.