We identified USP17 as a novel deubiquitinating enzyme regulating c-Myc levels to control cell proliferation. Overexpression of USP17 stabilized the c-Myc protein by promoting its deubiquitination ...

Together with our c-MYC data, we are demonstrating multiple unique and innovative strategies that leverage our deep RNA expertise to tackle currently intractable targets with new RNA-directed ...

They found that overexpression of c-Myc in Atp4b+ gastric parietal cells could induce gastric adenoma in mice. Mechanistically, c-Myc promoted tumorigenesis via the AKT/mTOR pathway.

Overexpression of the c-Myc oncoprotein is observed in a large number of hematopoietic malignancies, and transgenic animal models have revealed a potent role for c-Myc in the generation of ...

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In this study, JQ1H, which is a structural analogue of JQ1H, a typical indirect c-Myc inhibitor, was encapsulated inside functional nano-micelles, and their efficacy was evaluated.

PMR-116 shows promise in treating MYC-driven cancers, offering hope for patients with aggressive tumors in upcoming human trials.

The companies and academics are working to assess challenges and seek opportunities that could influence Proto oncogene protein c-myc inhibitors R&D. The therapies under development are focused on ...

RBM10 can inhibit lung cancer growth by suppressing the function of c-Myc, a protein that drives cancer cell growth when overexpressed.

UTR Therapeutics Inc. has submitted an IND application to the FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC-driven cancers. Pending approval, a first-in-human phase I trial is ...

Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer.