Blockade of 12-LOX expression suppresses Aβ-induced apoptosis and reduces Aβ-induced caspase activation. 12-LOX was previously shown to mediate both oxidative glutamate toxicity and apoptosis ...

4K. Space Launch System (SLS) Core Stage Green Run team members are working on new procedures to supply liquid oxygen (LOX) to the vehicle at lower temperatures in the next Wet Dress Rehearsal ...

Levels of the 12-LOX metabolite, 12(S)-HETE, were examined in 50 NSCLC serum samples, and correlated with serum VEGF. A panel of NSCLC cell lines were treated with baicalein (10 uM), a selective ...

VLX-1005 is a first-in-class, selective small molecule inhibitor of 12-lipoxygenase, a key target within the arachidonic acid pathway. In preclinical studies, VLX-1005 has been shown to halt ...

Veralox Therapeutics, a clinical-stage biotechnology company developing a new class of therapies targeting the 12-lipoxygenase (12-LOX) pathway, announced today that it has entered into an ...