Rookie running back Isaac Guerendo is not participating in Tuesday's practice session with the San Francisco 49ers. Guerendo ...

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

Kyle Shanahan shared his team's pre-practice injury report at a Tuesday press conference and it was the same as Monday's ...

The San Francisco 49ers will hold their lone full practice of a shortened week on Tuesday evening as they prepare for ...

San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 ...

The 49ers backfield is further and further depleted. Running back Isaac Guerendo is the latest to suffer an injury. We break ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The San Francisco 49ers are preparing for their Week 15 contest against the Los Angeles Rams on Thursday at Levi's Stadium in ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The rookie running back showed off on an impressive drive that included a long catch and TD run against the Bears.