The San Francisco 49ers have been dealing with injury issues all season, but Week 12's game against the Green Bay Packers feels like a different mountain to climb. In Week 12 the 49ers have already ruled out quarterback Brock Purdy and defensive end Nick Bosa.

Sunday's showdown at Lambeau Field may not come down to which side has the better team, but rather which squad better handles its many injuries.

Here are five things to watch and a prediction for Week 12:

Although Jordan Love has struggled all season with inconsistency, we expect the Green Bay quarterback to shine on Sunday against a 49ers team missing key pieces.

The Green Bay Packers opened as 1.5-point favorites for Sunday’s game against the San Francisco 49ers.After the 49ers ruled out quarterback Brock Purdy and defensive end Nick Bosa on Friday, the line moved to 5.

The Green Bay Packers ruled out cornerback Jaire Alexander and linebacker Edgerrin Cooper and listed defensive lineman Colby Wooden as questionable on the final injury report before facing the San Francisco 49ers in Week 12.

The Green Bay Packers are hosting the San Francisco 49ers in Week 12 in a battle between NFC foes. These two teams are fighting as the second-half playoff push is underway. The Packers sit at 7-3, meanwhile,

Green Bay Packers are favored against a struggling San Francisco 49ers in a crucial NFC matchup at Lambeau Field, with injuries hurting the 49ers' season.